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THE INTRAVENTRICULAR RESERVOIR IN THE TREATMENT OF NEUROLOGICAL DISEASE SECONDARY TO HEMATOLOGICAL MALIGNANCY: AN EIGHT YEAR EXPERIENCE
Author(s) -
YOUNG G. A. R.,
MILLIKEN S.,
JURD J.,
POULGRAIN P.,
VINCENT P. C.
Publication year - 1986
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1986.tb01190.x
Subject(s) - medicine , cerebrospinal fluid , chemotherapy , malignancy , neurotoxicity , acute leukemia , disease , leukemia , gastroenterology , toxicity
Between 1974 and 1982, 17 patients with central nervous system disease secondary to hematological malignancy had an intraventricular reservoir inserted to monitor their disease and to instil cytotoxic chemotherapy. Two other patients with acute lympho‐blastic leukemia and difficult access to the cerebrospinal fluid had a reservoir inserted to facilitate intrathecal chemotherapy. All 17 patients with established disease showed clinical improvement. Thirteen patients had complete elimination of malignant cells from the cerebrospinal fluid with cytotoxic chemotherapy, and the other four had a reduction in the concentration of malignant cells. Infection and neurotoxicity were found in a significant number of cases. and therefore the good clinical resDonse associated with th; procedure must be weighed carefully against the associated toxicity.