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COMBINED SPIRONOLACTONE AND CONVERTING‐ENZYME INHIBITOR THERAPY FOR REFRACTORY HEART FAILURE
Author(s) -
IKRAM H.,
WEBSTER M. W. I.,
NICHOLLS M. G.,
LEWIS G. R. J.,
RICHARDS A. M.,
CROZIER I. G.
Publication year - 1986
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1986.tb01119.x
Subject(s) - spironolactone , medicine , heart failure , diuresis , digitalis , refractory (planetary science) , cardiology , renal function , physics , astrobiology
Abstract Three cases are described of severe congestive heart failure which failed to respond to digitalis, high doses of loop diuretics, and converting‐enzyme inhibitors. The addition of spironolactone produced a substantial diuresis associated with clinical and radiological improvement in each case. Although a reversible deterioration in renal function was observed, this drug combination represents a therapeutic option in end‐stage heart failure.