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INFANTILE COMPLETE HEART BLOCK ASSOCIATED WITH MATERNAL Ro(SS‐A) RIBONUCLEOPROTEIN AUTOANTIBODIES: REPORT OF TWO CASES
Author(s) -
EPSTEIN R. J.,
McNEILAGE L. J.,
GATENBY P. A.,
HENDERSONSMART D. J.,
WHITTINGHAM S. F.,
BASTEN A.
Publication year - 1985
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1985.tb02737.x
Subject(s) - medicine , autoantibody , heart block , ribonucleoprotein , pregnancy , abortion , autoimmunity , immunology , antibody , heart disease , autoimmune disease , electrocardiography , rna , biochemistry , chemistry , genetics , biology , gene
:Two cases of congenital complete heart block arising during pregnancy were observed in association with a circulating maternal autoantibody to the soluble ribonucleoprotein Ro(SS‐A). Neither mother had clinical evidence of Sjogren's syndrome or systemic lupus erythematosus usually associated with anti‐Ro. However, both had a previous history of first‐trimester abortion and laboratory evidence of autoimmunity, and one gave a history of sialadenitis. Maternal anti‐Ro antibodies may be predictive of infantile heart block when present in pregnant women with overt or suspected multisystem autoimmune disease.