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VASCULITIS AND GLOMERULONEPHRITIS: A SUBGROUP WITH AN ANTINEUTROPHIL CYTOPLASMIC ANTIBODY
Author(s) -
HALL J. B.,
WADHAM B. McN.,
WOOD C. J.,
ASHTON V.,
ADAM W. R.
Publication year - 1984
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1984.tb03769.x
Subject(s) - medicine , anti neutrophil cytoplasmic antibody , vasculitis , glomerulonephritis , antibody , immunology , pathology , kidney , disease
Four subjects whose plasma produced positive staining of neutrophil cytoplasm, on testing for antinuclear factor, have been found over eight years (and over 10 000 antinuclear factor studies). All four had evidence of diffuse systemic disease with polyarthralgia and lung involvement. Three of four (at least) had evidence of renal involvement and two of four skin biopsy evidence of vasculitis. Defining such a subgroup may help in defining etiology(s) and treatment regimes in diffuse vasculitic disease.