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CONGENITAL HEPATIC FIBROSIS ASSOCIATED WITH MALLORY BODIES AND COPPER RETENTION
Author(s) -
EVANS J.,
HARRIS O.,
DETH A. G. VAN
Publication year - 1984
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1984.tb03627.x
Subject(s) - hepatic fibrosis , orcein , copper , congenital hepatic fibrosis , fibrosis , pathology , medicine , hepatic dysfunction , gastroenterology , chemistry , staining , cirrhosis , portal hypertension , organic chemistry
New observations are described in a case of congenital hepatic fibrosis. Histochemical stains of liver tissue for copper (rhodanine) and copper associated protein (orcein) were positive and hepatic copper concentration, measured by atomic absorption spectroscopy, was markedly elevated being 550 μg/g dry weight (NR <30 μg/g dry weight). Mallory bodies were observed in several areas in liver sections. These observations have not been previously recorded in congenital hepatic fibrosis. Increased hepatic copper concentration in this case may have contributed to the production of liver damage. Hepatic copper concentration should be specifically measured in other patients with congenital hepatic fibrosis.