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REACTIVE ARTHRITIS
Author(s) -
EDMONDS J.
Publication year - 1984
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1984.tb03597.x
Subject(s) - reactive arthritis , medicine , yersinia , arthritis , hla b27 , immunology , urethritis , synovitis , psoriatic arthritis , shigella , campylobacter , yersinia enterocolitica , salmonella , dermatology , human leukocyte antigen , antigen , biology , genetics , bacteria
Although sometimes used to refer to any sterile arthritis occurring in association with infection, the term ‘reactive arthritis’ is better reserved for arthritis following sexually acquired nonspecific urethritis or enteric infections with organisms such as Shigella, Salmonella, Yersinia and Campylobacter , because these arthropathies are unified by a number of shared clinical characteristics and an association with HLA B27. This review suggests that these arthropathies may also share a common pathogenic pathway, triggered by an ‘arthritogenic factor’ common to the diverse microbes which cause the disease and modified by genetic factors other than HLA B27. Although uncommon, reactive arthritis is important because it could provide the key to understanding the other seronegative arthropathies and mechanisms basic to chronic inflammatory synovitis. (Aust NZ J Med 1984; 14: 81–88.)