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CORRELATIONS BETWEEN FIBROBLAST ANDROGEN RECEPTOR LEVELS and CLINICAL FEATURES IN ABNORMAL MALE SEXUAL DIFFERENTIATION and INFERTILITY
Author(s) -
WARNE G. L.,
GYORKI S.,
RISBRIDGER G. P.,
KHALID B. A. K.,
FUNDER J. W.
Publication year - 1983
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1983.tb04476.x
Subject(s) - medicine , androgen receptor , infertility , sexual differentiation , male infertility , androgen , fibroblast , gynecology , andrology , endocrinology , pregnancy , genetics , biology , hormone , cancer , cell culture , prostate cancer , gene
Androgen receptor binding of radiolabelled methyltrienolone ( 3 H‐R1881) was determined in cultured genital skin fibroblasts from 17 normal male controls and from 65 males with genital abnormalities. Analysis of the results was performed with patients grouped according to the predominant clinical features. Of 16 patients with complete male pseudohermaphroditism, 12 had androgen receptor (AR) deficiency, one had “receptor‐positive” Testicular Feminization, and in three, alternative diagnoses were established (17ahydroxylase deficiency; 20,22‐desmolase deficiency; mixed gonadal dysgenesis). In contrast, only four of 16 patients investigated for ambiguous genitalia (phallus intermediate between male and female, perineal urethra) showed AR deficiency. Borderline or slightly low AR levels were found in each of four boys in whom the sole abnormality was micropenis. In 26 boys with penile hypospadias, however, only one had low AR. Very low levels of AR (levels comparable to those seen in complete Testicular Feminization) were found in two of three men with infertility associated with abnormally high serum testosterone levels.