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SUCCESSFUL TREATMENT OF ACUTE DAPSONE INTOXICATION USING CHARCOAL HEMOPERFUSION
Author(s) -
ENDRE Z. H.,
MACDONALD G. J.,
CHARLESWORTH J. A.,
WOODBRIDGE L.
Publication year - 1983
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1983.tb02704.x
Subject(s) - hemoperfusion , dapsone , medicine , methemoglobinemia , charcoal , hemolysis , activated charcoal , anesthesia , dialysis , surgery , hemodialysis , dermatology , chemistry , materials science , organic chemistry , adsorption , metallurgy
A 22 year old female was admitted to hospital two hours after ingesting 4 g of dapsone. Over the next 15 h she developed progressive hemolysis and methemoglobinemia. Charcoal hemoper‐fusion and sequential dialysis were performed because of the serious risk of fatality following such a massive dose of dapsone. Charcoal hemoperfusion led to rapid clearing of dapsone from the circulation. This resulted in clinical improvement and controlled the progression of hemolysis and methemoglobinemia.