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DIPHOSPHONATES AND PAINFUL FEET
Author(s) -
EVANS R. A.,
MACDONALD D.
Publication year - 1983
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1983.tb02676.x
Subject(s) - medicine , diphosphonates , stress fractures , tenderness , myositis ossificans , foot (prosody) , etidronic acid , surgery , nuclear medicine , bone resorption , osteoporosis , linguistics , philosophy
Abstract: Localised foot pain occurred in four patients with Paget's disease of bone or myositis ossificans who were treated with disodium etidronate (EHDP) in a dose of 10 to 20 mg/kg body weight/day for four to six months. There was localised tenderness and sometimes slight swelling at the painful areas. Bone x‐rays were normal, but bone scans showed increased uptake of the isotope at these areas. The pain persisted for several weeks, causing considerable difficulty in walking. The symptoms were most likely due to diphosphonate‐induced stress fractures. These cases emphasise the importance of administering EHDP in low dosage for short periods only.