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TUMOUR VISUALISATION USING A RADIOLABELLED MONOCLONAL ANTIBODY *
Author(s) -
ZALCBERG J. R.,
THOMPSON C. H.,
LICHTENSTEIN M.,
LEYDEN M. J.,
ANDREWS J. T.,
SULLIVAN J. R.,
McKENZlE I. F. C.
Publication year - 1983
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1983.tb02605.x
Subject(s) - medicine , monoclonal antibody , antibody , carcinoma , epithelioma , pathology , colon carcinoma , nuclear medicine , colorectal cancer , immunology , cancer
A radiolabelled monoclonal antibody was injected intravenously into two patients with disseminated carcinoma of the colon and serial scintigrams were then obtained on three consecutive days. In addition to the “specific” antibody image, blood pool and conventional liver scans were also obtained. After computer‐based subtraction discrete hepatic metastases could be demonstrated in both patients, while in the second patient, the primary colonic tumour was also visualised for the first time. The study demonstrates the specific localisation of primary and secondary carcinoma of the colon with a radiolabelled monoclonal anti‐tumour antibody and offers an improved method of specifically detecting tumours in man. (Aust NZ J Med 1983; 13: 571–577.)