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Comparison of Sodium and Calcium Heparin in Prevention of Venous Thromboembolism
Author(s) -
Cade J. F.,
Andrews J. T.,
Stubbsi A. E.
Publication year - 1982
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1982.tb03831.x
Subject(s) - heparin sodium , heparin , medicine , placebo , calcium , partial thromboplastin time , anesthesia , anticoagulant , sodium , surgery , chemistry , coagulation , pathology , alternative medicine , organic chemistry
Comparison of sodium and calcium heparin in prevention of venous thromboembolism. J. F. Cade, J. T. Andrews and A. E. Stubbs. Aust. HZ. J. Med., 1982, 12 , pp. 501–504. The relative efficacy of sodium and calcium heparin in preventing venous thromboembolism and their relative side‐effects were studied in 234 high‐risk patients in a randomised, double‐blind, placebo‐controlled trial. The two heparin preparations were from the same batch and in the same concentration, and were given in a dose of 5000 U 12 hourly. Positive leg scans were found in 19% after placebo, 12% after sodium heparin and 8% after calcium heparin. Bruising at the injection site was more common after calcium heparin (66%) than after sodium heparin (53%) or placebo (38%). Pain at the injection site was also more common after calcium heparin (26%) than after sodium heparin (8%) or \ placebo (6%). Changes in the activated partial thromboplastin time were small and did not correlate with leg scan results or bruising. While there was a tendency for calcium heparin to be possibly more effective, it was followed by significantly more local haema toma and pain.