Premium
Mebhydrolin Induced Agranulocytosis
Author(s) -
Young G. A. R.,
Forrest P.,
Deveridge S. F.,
Gates R. B.,
Vincent P. C.
Publication year - 1982
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1982.tb02452.x
Subject(s) - medicine , monocyte , lithium carbonate , leukopenia , immunology , chemotherapy , chemistry , ion , organic chemistry , ionic bonding
Mebhydrolin induced agranulocytosis . G. A. R. Young, P. Forrest, S. F. Deveridge, R. B. Gates and P. C. Vincent, Aust. N.Z. J. Med., 1982,12, pp. 173–176. Two cases of agranulocytosis are described, in which the antihistamine mebhydrolin (Fabahistin, Bayer) was taken shortly before the onset of agranulocytosis. In one case, agar culture techniques demonstrated that the patient's acute phase plasma in the presence of complement inhibited the growth of granulocyte/monocyte precursor cells (CFU–C) from her marrow. Both patients recovered; in one, lithium carbonate may have aided recovery.