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Comparison of Ipratropium Bromide and Salbutamol by Aerosolized Solution
Author(s) -
Jenkins C. R.,
Chow C. M.,
Fisher B. L.,
Marlin G. E.
Publication year - 1981
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1981.tb04621.x
Subject(s) - ipratropium bromide , salbutamol , medicine , aerosolization , anesthesia , saline , ipratropium , inhalation , bromide , asthma , bronchodilator , chemistry , organic chemistry
lpratropium bromide (0,125 mg, 0.25 mg and 0.5 mg) and salbutamol (5 mg) by aerosolized solution produced equivalent peak broncho‐dilatation between one and two hours after administration to ten patients with chronic partially reversible airways obstruction. The duration of action of the two higher doses of ipratropium bromide (0.25 mg —6 hours; 0.5 mg — 5 hours) was significantly greater than salbutamol (4 hours). FVC increases with both drugs and saline were greater than FEV, increases which may indicate dilatation of small peripheral airways or removal of bronchial mucus from these sites after coughing. A dose of 0.25 mg ipratropium bromide as an aerosolised solution is recommended for clinical use .