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Glyoxalase Phenotypes in Patients with Diabetes Mellitus
Author(s) -
McCann V. J.,
Davis R. E.,
Welborn T. A.,
Constable I. J.,
Beale D. G.
Publication year - 1981
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1981.tb03516.x
Subject(s) - medicine , lactoylglutathione lyase , diabetes mellitus , methylglyoxal , phenotype , insulin , diabetic retinopathy , endocrinology , nph insulin , type 2 diabetes mellitus , type 2 diabetes , gene , enzyme , genetics , biology , biochemistry , insulin glargine
Caucasian diabetic patients in Australian surveys showed a significant difference in the distribution of glyoxalase phenotypes. Insulin dependent diabetic patients with age of onset less than 40 years had a relative excess of glyoxalase homozygote 1–1 and a deficiency of types 2–7 and 2–2. Non‐insulin dependent diabetic patients were not significantly different from non‐diabetic subjects in the distribution of glyoxalase phenotypes . Insulin dependent diabetic patients without the complications of retinopathy or neuropathy also showed a significant excess of glyoxalase type 1–1 in relation to the control group. Genes controlling glyoxalase polymorphism appear to be associated with the variations of diabetes and its complications.