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Rifampicin Associated Renal Dysfunction During Antituberculous Therapy
Author(s) -
Need A. G.,
Phillips P. J.,
Chiu F. T. S.,
Clarkson A. R.
Publication year - 1980
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1980.tb04249.x
Subject(s) - medicine , chills , rifampicin , ethambutol , renal function , proteinuria , intensive care medicine , tuberculosis , kidney , pathology
Summary Intermittent rifampicin therapy has been reported to commonly cause a flu‐like illness with chills and fever sometimes associated with acute renal failure. This report describes a fourth case of partially reversible insidious renal damage associated with continuous rifampicin therapy and provides evidence that it is not the result of light chain proteinuria as previously suggested. A retrospective review of data relating to renal function in 89 tuberculous patients indicated that increased plasma urate concentration was commonly associated with ethambutol therapy.