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Cimetidine and Acute Upper Gastrointestinal Bleeding: A Double‐blind Controlled Trial
Author(s) -
Meredith C. G.,
Kennedy M. C.,
Wade D. N.,
Sweeten M. V.,
Byrnes D. J.,
Frommer D. J.,
Hennessy W. B.
Publication year - 1980
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1980.tb04241.x
Subject(s) - cimetidine , medicine , placebo , incidence (geometry) , gastrointestinal bleeding , upper gastrointestinal bleeding , double blind , anesthesia , surgery , clinical trial , placebo group , endoscopy , physics , alternative medicine , pathology , optics
Summary Patients presenting with acute upper gastrointestinal bleeding from a variety of lesions were admitted to a prospective double‐blind controlled trial to determine if Cimetidine reduces the severity of bleeding and/o r the incidence of rebleeding. During the first 48 hours, the patients received intravenous cimetidine (200 mg four‐hourly) or placebo, and for the following ten days, oral Cimetidine (1 g/24 hr) or placebo. Eighty‐eight patients entered the trial of whom 45 (51%) were in the cimetidine‐treated group. Six of the seven patients requiring surgery for life‐threatening bleeding and four of the six patients who rebled were in the cimetidine‐treated group. This study failed to demonstrate any advantage of using Cimetidine routinely in the treatment of acute upper gastrointestinal bleeding.