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Effects of Cimetidine on the Healing of Benign Gastric Ulcers
Author(s) -
Clarke A. C.,
Lee S. P.,
TasmanJones C.
Publication year - 1980
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1980.tb04095.x
Subject(s) - cimetidine , medicine , placebo , stomach ulcers , gastroenterology , clinical trial , surgery , stomach , alternative medicine , pathology
Summary: A prospective double‐blind trial was undertaken to determine whether treatment with cimetidine influenced the healing of gastric ulcers in New Zealand patients. Ulcer size and healing was assessed by endoscopic examination. Of the 30 patients who completed the trial, 15 were given cimetidine and 15 placebo. At six weeks, 60% of the patients on cimetidine had healed their ulcers, whereas only 20% of those on the placebo had healed ulcers (P < 0·05). Fewer patients taking cimetidine required antacids for symptom control than those on placebo treatment (P < 0·05). The study confirmed that cimetidine treatment accelerates the healing of gastric ulcers.