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Selective IgA Deficiency in Australian Blood Donors
Author(s) -
Wells J. V.,
McNally M. P.,
King M. A.
Publication year - 1980
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1980.tb04091.x
Subject(s) - medicine , iga deficiency , antibody , blood transfusion , selective iga deficiency , immunology , blood donor , immunoglobulin a , immunoglobulin g
Summary: Selective serum IgA deficiency (defined as a serum IgA level less than 50 mgll) was detected in 14 of 6, 191 Australian blood donors screened by double diffusion analysis of serum specimens in agarose. This prevalence rate of 0·23% (1 in 442) is the same as that found in blood donors in Sweden but is higher than rates found in blood donors in France (0·05%), Norway (0·08%), USA (0·15%), England (0·19%) and Finland (0·20%). Antibodies to human IgA were detected in the serum of three of 11 blood donors with selective IgA deficiency (27%). There was no evidence in the present study of blood transfusion reactions from these anti‐IgA antibodies when they were transfused into recipients.