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Thyrotrophin Displacement Activity of Serum Immunoglobulins in Health and Disease
Author(s) -
Croxson M. S.,
Lim T. M. T.,
Graham F. M.,
Ibbertson H. K.
Publication year - 1980
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1980.tb03703.x
Subject(s) - carbimazole , medicine , euthyroid , thyroiditis , graves' disease , endocrinology , antithyroid drugs , gastroenterology , antibody , disease , thyroid , immunology
Summary: Thyrotrophin displacement activity of serum immunoglobulins in health and disease. M. S. Croxson, T. M. T. Lim, F. M. Graham and H. K. Ibbertson, Aust. N.Z. J. Med ., 1980, 10, pp. 151–156. A radioreceptor assay for TSH displacement activity (TDA) was employed as an index of thyroid stimulating immunoglobulins (TSIg) in serum from patients with autoimmune thyroid disease. TDA was > 20 in normal subjects (37/37), patients without thyroid disease (36/38), non‐toxic goitre (18/19) and toxic nodular goitre (16/17) and was significantly lower in Nepalese subjects with severe endemic goitre. TDA was > 20 in 84% of patients with untreated hyperthyroid Graves' disease (70/83), in Hashimoto's thyroiditis (3/17) and following subtotal thyroidectomy (8/14) or 131 I therapy (7/11), but was ≤ 20 in euthyroid patients treated with carbimazole (58/59) and during spontaneous remission (18/19). Serial TDA measurements during antithyroid drug therapy suggested that carbimazole has a direct effect in reducing TS/g concentration but that TDA is not a useful prognostic indicator of short term relapse or remission