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Immune Thrombocytopenia Induced by Cotrimoxazole
Author(s) -
Barr A. L.,
Whineray M.
Publication year - 1980
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1980.tb03420.x
Subject(s) - medicine , immune thrombocytopenia , autoantibody , immunology , hapten , platelet , immune system , drug , antibody , pharmacology
Summary: Immune thrombocytopenia induced by cotrimoxazole. A. L. Barr and M. Whineray. Aust. N.Z. J. Med ., 1980, 10 , pp. 54–55. Cotrimoxazole administration is occasionally associated with thrombocytopenia. Interference with folate metabolism has been postulated. 2 The drug has also been postulated to induce an autoantibody by acting as a hapten 3 , but proof has not been forthcoming. A case is reported in which the serum has been shown to contain an anti‐platelet autoantibody requiring sulphamethoxazole or cotrimoxazole for activity.