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A Case of Paroxysmal Nocturnal Haemoglobinuria Terminating in a Myeloproliferative Syndrome
Author(s) -
Boyd A. W.,
Parkin J. D.,
Castaldi P. A.
Publication year - 1979
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1979.tb04325.x
Subject(s) - medicine , leukocytosis , myeloproliferative disorders , polycythemia rubra vera , haemolysis , pediatrics , bone marrow , polycythemia vera , immunology
Summary: This report discusses the case of a 60‐year‐old man who presented in 1969 with thrombocyto‐penia and mild marrow hypoplasia. A diagnosis of paroxysmal nocturnal haemoglobinuria (PNH), was established. The subsequent course included episodes of overt intra‐vascular haemolysis. Thrombocytopenia reverted on several occasions during Oxymetholone therapy. The terminal phase of the illness was marked by the development of a leukocytosis and densely hypercellular bone marrow with splenomegaly. The features were those of a myeloproliferative disorder, although frank leukaemia did not develop.