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The Association of Haemopoietic Dysplasia (Pre‐leukaemia) and Abnormal Cell Clone with Connective Tissue Disease
Author(s) -
Lee C. H.,
Liew S. K.,
Fleming A.,
LamPoTang P. R. L. C.,
Rozenberg M. C.
Publication year - 1979
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1979.tb04324.x
Subject(s) - medicine , clone (java method) , connective tissue , pathology , dysplasia , connective tissue disease , disease , bone marrow , immunology , autoimmune disease , biology , genetics , dna
Summary: A 68‐year‐old man with haemotological features consistent with haemopoietic dysplasia (pre‐leukaemia) and an abnormal cell clone in the marrow, 46, XY,‐18, + t(13;18) (q11;123), developed acute connective tissue disease characterised by vasculitis, dermal changes, marked muscular weakness and serological features suggesting an autoimmune disturbance. Although four other cases of haemopoietic dysplasia (“pre‐leukaemia”) with unusual connective tissue disease had been reported since the recognition of haemopoietic dysplasia as a distinct entity, a definite association between these two disease states still awaits confirmation by further reports and investigations.