Premium
Release of Secretin—Plasma Levels Reproduced by Exogenous Infusion
Author(s) -
Byrnes D. J.,
Marjason J.,
Henderson L.,
Lazarus L.
Publication year - 1979
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1979.tb04319.x
Subject(s) - secretin , duodenum , medicine , endocrinology , plasma levels , plasma concentration , human plasma , gastrointestinal hormone , peptide hormone , chemistry , pancreas , hormone , chromatography
Summary: Infusion of 0.1 M HCI (0.5 mmol/kg/hr over 20 minutes) into the duodenum of each of seven normal subjects led to a significant rise (P<0.05) in mean plasma secretin levels from 3.0±2.2 (SE) to 15±4.0 pmol/l. Intravenous infusion of secretin at a rate of 6–6 pmol/kg/hr (0.08 clinical units/kg/hr) reproduced the peak plasma levels of secretin observed during duodenal acidification. However, there was no detectable (2.5 pmol/l) change in plasma secretin after oral protein or glucose.