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Serum Immune Complexes and Disease
Author(s) -
Woodroffe A. J.,
Foldes M.,
McKenzie P. E.,
Thompson A. J.,
Seymour A. E.,
Clarkson A. R.
Publication year - 1979
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1979.tb04315.x
Subject(s) - medicine , immune system , glomerulonephritis , immunology , immune complex , rheumatoid arthritis , pathogenesis , infective endocarditis , immune complex disease , rapidly progressive glomerulonephritis , vasculitis , disease , pathology , kidney
Summary: The solid phase Clq radioimmunoassay was used to detect immune complexes in sera from patients with systemic lupus erythematosus (14/25), rheumatoid arthritis (4/5), vasculitis (5/15), infective endocarditis (2/2), acute rheumatic fever (2/3), pre‐eclamptic toxaemia (0/14), lung cancer (3/7), glomerulonephritis (26/98) and renal transplant patients (0/5). The best correlation with disease activity was seen in systemic lupus erythematosus and infective endocarditis where serial immune complex determinations were clearly of value in monitoring therapy. The findings in primary glomerulonephritis indicate only a limited usefulness of the assay in that serum immune complexes were detected in a minority (22/73) of patients with glomerular immune deposits. In particular the data do not support a role for Clq fixing immune complexes in the pathogenesis of membranous glomerulonephritis or in pre‐eclamptic toxaemia.