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Heparinized Chemotherapy in the Treatment of Disseminated Lung Cancer
Author(s) -
Jamieson G. G.,
Angove R. C.
Publication year - 1979
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1979.tb04163.x
Subject(s) - medicine , chemotherapy , vincristine , cyclophosphamide , heparin , methotrexate , lung cancer , surgery , pleural effusion , lung , cancer , disseminated intravascular coagulation , oncology , gastroenterology
Summary: Heparinized chemotherapy in the treatment of disseminated lung cancer. G. G. Jamieson and R. C. Angove, Aust. N.Z. J. Med., 1979, 9, pp. 381–384. Fourteen patients with inoperable or metastatic carcinoma of the lung were entered in this study. All of them received one or more courses of multiple chemotherapy (cyclophosphamide, 5‐fluorouracil, methotrexate and vincristine) with prior and concurrent heparin ant/coagulation. No tumour regression was noted in any patient although one patient is alive and well at two years. Five patients developed sudden increase in pleural effusion whilst on heparin therapy and in four of these patients the effusion was a significant factor in their death.