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The Relevance of 25‐Hydroxycalciferol Measurements in Sera of Patients with Renal Failure*
Author(s) -
Mason R. S.,
Moddel D.,
McElduff A.,
Stewart J. H.,
Mahony J. F.,
Posen S.
Publication year - 1979
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1979.tb04134.x
Subject(s) - osteomalacia , medicine , parathyroid hormone , iliac crest , serum concentration , endocrinology , gastroenterology , clinical significance , vitamin d and neurology , surgery , calcium
Summary: Iliac crest biopsies and serum specimens were obtained from 36 non‐dialyzed uraemic patients. The mean serum 25‐hydroxycalciferol concentration of the patients was lower than that of normal subjects and a significant correlation was found between 25‐hydroxycalciferol values and the severity of osteomalacia. Parathyroid osteopathy was significantly correlated with serum immunoreactive parathyroid hormone but not with serum 25‐hydroxycalciferol values. While normal serum 25‐hydroxycalciferol concentrations in uraemic patients do not exclude the presence of osteomalacia, a low concentration is virtually diagnostic of this disorder.