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Growth Failure, Somatomedin and Growth Hormone Levels in Juvenile Diabetes Mellitus—A Pilot Study
Author(s) -
Nash H.
Publication year - 1979
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1979.tb04131.x
Subject(s) - somatomedin , medicine , endocrinology , growth hormone , diabetes mellitus , dwarfism , malnutrition , insulin , growth retardation , hormone , pregnancy , biology , gene , biochemistry , genetics
Summary: Growth hormone (hGH) responsiveness to exercise and Somatomedin C (SmC) activity were measured in ten children with insulin‐deficient diabetes mellitus. Four of the ten children showed a significant degree of growth retardation. Normal SmC activity was found in association with elevated hGH levels. The hypothesis that growth‐retarded diabetics have a failure of Sm production despite high hGH levels (analogous to malnutrition and Laron dwarfism) was not substantiated by this study. Chronic deficiency of insulin, itself a somatomedin, may play a major role in diabetic growth failure.