Premium
Alpha1 ‐Antitrypsin Deficiency–A Literature Review and a Case Report of a Patient with Chronic Obstructive Airways Disease and Cirrhosis
Author(s) -
Coughlin G. P.,
Deth A. G.,
Ey G. T.,
Grant A. Kerr
Publication year - 1977
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1977.tb04404.x
Subject(s) - medicine , cirrhosis , alpha 1 antitrypsin deficiency , pulmonary function testing , disease , gastroenterology , liver disease , chronic liver disease , pulmonary disease
Summary:Alpha,‐antitrypsin deficiency—a literature review and a case report of a patient with chronic obstructive airways disease and cirrhosis. G. P. Coughlin, A. G. van Deth, G. T. Ey and A. Kerr Grant, Aust. N.Z. J. Med. , 1977, 7, pp. 400–403. A patient who manifested both pulmonary and hepatic disease associated with alpha 1 ‐antitrypsin deficiency is described. The biological function of alpha, ‐antitrypsin is discussed, as well as the inheritance of deficiency states and the spectrum of disorders which may ensue. Severe deficiency of alpha 1 ‐antitrypsin has been linked with pulmonary emphysema in adult life, progressive liver disease in childhood, adult cirrhosis but rarely with both pulmonary and liver disease.