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Watery Diarrhoea Syndrome with Episodic Hypercalcaemia
Author(s) -
Holdaway I. M.,
Evans M. C.,
Clarke E. D.
Publication year - 1977
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1977.tb03360.x
Subject(s) - hypercalcaemia , medicine , endocrinology , vasoactive intestinal peptide , gastroenterology , parathyroid hormone , parathyroid adenoma , calcium , adenoma , receptor , neuropeptide
Summary Watery diarrhoea syndrome with episodic hypercalcaemia. I. M. Holdaway, M. C. Evans and E. D. Clarke, Aust. N.Z. J. Med., 1977 , 7 . pp. 63–65. A patient with the Watery‐Diarrhoea syndrome and episodic hypercalcaemia is reported. Plasma levels of vasoactive intestinal peptide (VIP) were elevated, and an islet cell adenoma of the pancreas was removed following which VIP levels decreased and diarrhoea ceased. During a hypercalcaemic episode, serum parathyroid hormone (PTh) levels were suppressed indicating the hypercalcaemia was independent of PTh and probably due to a direct action of VIP on calcium turnover.