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Systemic Herpes Simplex Infection with Fulminant Hepatitis Post‐Transplantation
Author(s) -
Holdsworth S. R.,
Atkins R. C.,
Scott D. F.,
Hayes K.
Publication year - 1976
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1976.tb04002.x
Subject(s) - medicine , immunosuppression , fulminant , immunology , fulminant hepatitis , herpes simplex virus , transplantation , hepatitis , virology , virus
Summary: Systemic herpes simplex infection with fulminant hepatitis post‐transplantation. S. R. Holdsworth, R. C. Atkins, D. F. Scott and K. Hayes, Aust. N.Z. J. Med. 1976, 6, pp. 588–590. Immunosuppression for renal transplantation is associated with the risk of severe overwhelming infection with ubiquitous but normally relatively harmless micro‐organisms. In recent years a number of adult cases of fatal hepatitis due to herpes simplex virus (HSV) infection have been reported. Nearly always immune deficiency was a significant factor. A case of fatal HSV infection with hepatitis following transplantation is reported. The case failed to respond to infusion with the antiviral agent cytosine arabinoside. The presentation, diagnosis and treatment of HSV fulminant hepatitis is discussed.