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Once Daily Dosage Beta‐Blockade: Antihypertensive Efficacy of Slow Release Oxprenolol as Related to Renin and Age
Author(s) -
Bühler F. R.,
Lütold B. E.,
Küng M.,
Koller F. J.
Publication year - 1976
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1976.tb03333.x
Subject(s) - oxprenolol , medicine , blockade , blood pressure , renin–angiotensin system , diuretic , plasma renin activity , beta blocker , regimen , beta (programming language) , heart rate , diastole , pharmacology , cardiology , endocrinology , heart failure , receptor , computer science , programming language
Summary: Once daily dosage beta‐blockade: Antihypertensive efficacy of slow release oxprenolol as related to renin and age. A single daily dose antihypertensive therapy with a new slow‐release (SR) form of the beta‐adrenoceptor blocking agent oxprenolol was as effective as a standard tid beta‐blocker regimen in maintaining therapeutic effects over 24 hours. The good overall response rate (target ≤ 95 mmHg diastolic) of 67% was achieved in eight of the 11 high renin patients and 16 out of the 20 normal renin ones; the five low renin patients, who were also older, proved to be non‐responsive. In terms of age, 83% of the patients aged under 40 years showed a reduction in diastolic pressure to ≤ 95 mmHg, this percentage being significantly better than the 50% response rate in the 40–56‐year‐olds. In nine of the 12 beta‐blocker non‐responders the diastolic blood pressure was reduced to ≤ 95 mmHg by adding a diuretic, and in four of the nine, all of them low renin patients, this effect persisted in response to diuretics alone. Oxprenolol SR suppresses renin acutely (59%) and chronically (62%), and it blunts the renin stimulatory effects of diuretics.