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Changes in Plasma Lipoproteins in Subjects Treated with the Bile Acid‐Sequestering Resin Polidexide (Secholex®)
Author(s) -
Simons L. A.,
Williams P. F.
Publication year - 1976
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1976.tb03305.x
Subject(s) - medicine , triglyceride , plasma lipoprotein , apolipoprotein b , endocrinology , cholesterol , bile acid , plasma levels , plasma concentration , lipoprotein
Summary:Changes in plasma lipoproteins in subjects treated with the bile acid‐sequestering resin polidexide (Secholex ® ). L. A. Simons and P. F. Williams, Aust. N.Z. J. Med. , 1976, 6 , pp. 1 27–130 The effects of a new anion‐exchange resin, polidexide, 3–30 grams/day, on plasma lipids and lipoproteins have been studied in one normal subject and in three hyperlipidaemic patients. Plasma cholesterol concentrations were significantly reduced in all subjects over 80–120 days of therapy by amounts ranging from 14 to 20%. Plasma triglyceride concentrations increased in two patients with pre‐existing hypertriglyceridaemia. Plasma apolipoprotein‐B concentrations were reduced in all subjects. Cholesterol and apo‐B concentrations in low density lipoproteins were reduced in all subjects, while triglyceride concentrations in very low density lipoproteins were increased in 3/4 subjects. Changes in high density lipoproteins were quite variable.