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Ectopic Adrenocorticotrophic Hormone Production and Neoplasm
Author(s) -
Pinerua R. F.,
Dunn C. M.
Publication year - 1975
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1975.tb04581.x
Subject(s) - adrenocorticotrophic hormone , medicine , neoplasm , hormone , endocrinology , pathology
Summary: Three patients presented with severe hypokalaemic, hypochloraemic alkalosis, muscle weakness and later cutaneous pigmentation. There were few signs of Cushing's syndrome. Two had bronchial and one pancreatic neoplasm. Plasma cortisol and urinary steroid metabolites were extremely elevated and synacthen stimulation showed significant adrenal capacity even with adrenal metastases. Aminoglutethamide reduced plasma cortisol in two patients.