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The Effect of Carbenoxolone Sodium on the Plasma 11 Hydroxycorticoid Levels in Chronic Gastric Ulceration
Author(s) -
Gollan J. L.,
Heckert R.,
Mackin A. M.
Publication year - 1975
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1975.tb04574.x
Subject(s) - carbenoxolone , medicine , endocrinology , aldosterone , gastroenterology , intracellular , gap junction , biology , microbiology and biotechnology
Summary: The effect of carbenoxolone sodium on the plasma 11 hydroxycorticoid levels in chronic gastric ulceration. The mineralocorticoid effects of carbenoxolone sodium are well established and seem related to the ulcer healing of the drug. In the present study the plasma 11 hydroxycorticoid responses were assessed in 12 patients undergoing treatment with carbenoxolone for chronic gastric ulceration. After treatment with carbenoxolone for one month the plasma 11 hydroxycorticoid levels rose significantly, suppression by dexamethasone was less marked and the normal diurnal periodicity was abolished. Carbenoxolone therapy influences the results of tests designed to assess the function of the pituitary‐adrenal axis and may lead to sub‐clinical adrenocortical hyperfunction.