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Properdin and Recurrent Macroscopic Haematuria
Author(s) -
Roy L. Paul
Publication year - 1975
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1975.tb04566.x
Subject(s) - properdin , alternative complement pathway , complement system , medicine , complement (music) , immunology , complement c1q , complement factor b , classical complement pathway , antibody , biology , biochemistry , mutant , complementation , gene
Summary: Kidney biopsies from ten children with recurrent macroscopic haematuria, showed mesangial deposition of IgG, IgA and complement. Eight of these ten biopsies also showed deposition of properdin, a basic euglobulin intimately involved in the alternate pathway of complement activation. Serum haemolytic complement activity was normal in the eight patients tested. Incubation of the serum at 4 °C for 24 hours did not result in any change in complement activity. These data suggest that the mesangial inflammatory process in these patients may be mediated in part by the alternate pathway of complement activation and that the mechanism is activated locally.