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Salmonella Meningitis Treatment with Intravenous Trimethoprim
Author(s) -
Briggs A. E.,
Robinson M. F.
Publication year - 1975
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1975.tb03273.x
Subject(s) - medicine , meningitis , trimethoprim , salmonella , sulfamethoxazole , intensive care medicine , antibiotics , microbiology and biotechnology , surgery , bacteria , genetics , biology
Summary: Intravenous trimethoprim and sulphadiazine were used in the successful treatment of Salmonella meningitis in a four months old child. Pharmacological data are presented which show good penetration of the blood‐brain barrier by trimethoprim. This combination appears to be a useful alternative therapy for gram‐negative meningitis. Trimethoprim is a bacterial dihydrofolate reductase inhibitor which is currently administered in conjunction with Sulphamethoxazole as an oral preparation. Recently a parenteral preparation of trimethoprim (Trimethoprim Lactate Burroughs‐Wellcome) has become available for restricted use. We report our experience with the USC of this drug in an infant with Salmonella meningitis.