Premium
Symptomatic Hypergastrinaemia with Achlorhydria: Relief by Antrectomy *
Author(s) -
Thompson C. D.,
Mackay I. R.,
Hansky J.
Publication year - 1975
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1975.tb03271.x
Subject(s) - achlorhydria , medicine , gastrin , abdominal pain , gastritis , pain relief , gastroenterology , pernicious anaemia , pentagastrin , meal , stomach , endocrinology , surgery , gastric acid , secretion
Summary: A woman had hypergastrinaemia associated with the variety of gastritis (Type A) that is associated usually with pernicious anaemia, together with recurring bouts of severe abdominal pain. Fasting serum gastrin levels ranged between 600 and 2750 pg/ml. There was a rise in serum gastrin levels after a standard protein meal, indicative of a large G cell mass, and a fall after intragastric HCI, which led to a trial of treatment with HCI; this gave some symptomatic relief. After surgical antrectomy there was a profound fall of serum gastrin from a pre‐operative level of 2500 pg/ml to constant values of 16–25 pg/ml, and complete and lasting relief from the bouts of abdominal pain.