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Histiocytic Medullary Reticulosis
Author(s) -
Sullivan J. R.,
Ungar B.,
Hicks J. D.,
Hurley T. H.
Publication year - 1975
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1975.tb03270.x
Subject(s) - histiocyte , malignant histiocytosis , medicine , histiocytosis , medullary cavity , pathology , phagocytosis , pathological , histiocytic sarcoma , splenectomy , platelet , lymphatic disease , immunology , spleen , disease
Summary: The clinical and pathological features of histiocytic medullary reticulosis (HMR) are described in five patients. Treatment by splenectomy and the MOPP routine resulted in a transient improvement in platelet and neutrophil counts and resolution of anaemia and apparent prolongation of survival in two of the five patients. The relationship of HMR to other histiocytic disorders is discussed. HMR is defined as a unique malignant histiocytosis in which malignant histiocytes engage in phagocytosis of erythrocytes, leucocytes and platelets.