Premium
Cobalt Chloride in the Treatment of Refractory Anaemia in Patients undergoing long‐term Haemodialysis
Author(s) -
Bowie E. A.,
Hurley P. J.
Publication year - 1975
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1975.tb03263.x
Subject(s) - medicine , refractory (planetary science) , cobalt , term (time) , surgery , intensive care medicine , metallurgy , physics , materials science , quantum mechanics
Summary: E. A. Bowie and P. J. Hurley, The effect of oral cobalt chloride on the anaemia of patients undergoing long‐term haemodialysis therapy was investigated in 14 patients taking 25 mg then 50 mg daily. After eight weeks of treatment the mean haematocrit increase in 11 patients completing the trial was 23% of the original level and the 51 Cr‐red cell volume had increased by 20%. The 51 Cr red cell half‐life lengthened after treatment in six patients and the 59 Fe plasma half‐time shortened in ten patients. After treatment, evidence of increased erythropoietic activity was seen in the bone marrow of five patients. No evidence was found of thyroid or liver dysfunction but three patients developed transient loss of hearing demonstrated by audiometry. Cobalt chloride appears to be helpful in the management of some uraemic patients with refractory anaemia.