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Urinary Excretion of Cyclic AMP in Primary Hyperparathyroidism **
Author(s) -
Bartley Paul C.,
Willgoes D.,
Lloyd H. M.
Publication year - 1975
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1975.tb03252.x
Subject(s) - medicine , primary hyperparathyroidism , parathyroidectomy , urinary system , endocrinology , excretion , urology , parathyroid hormone , calcium
Summary: Urinary adenosine 3′ 5′‐cyclic monophosphate (cyclic AMP) was assessed by a competitive protein binding method in 19 patients with primary hyperparathyroidism (PHPT) and in 15 control subjects. The mean value of 6.6 ± S.E. 0.64 μM per 24 hours for the patients with PHPT was higher ( P < 0.001) than the mean control value of 3.2 ±24μM per 24 hours. In all hypercalcaemic patients without renal insufficiency, urinary cyclic AMP excretion was more than 4 μM per 24 hours and decreased in the 15 patients investigated after parathyroidectomy. In a normocalcaemic hyperparathyroid patient and in three hyperparathyroid patients with renal insufficiency, urinary cyclic AMP was less than 4 μM per 24 hours.