Premium
Interaction of Bile with Erythromycin Lactobionate in vitro *
Author(s) -
Clarke A. E.,
Maritz V. M.,
Denborough M. A.
Publication year - 1975
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1975.tb03250.x
Subject(s) - erythromycin , medicine , cholestasis , in vitro , pharmacology , in vivo , gastroenterology , antibiotics , biochemistry , chemistry , biology , microbiology and biotechnology
Summary: An interaction of bile with erythromycin lactobionate in vitro has been demonstrated. The major bile components involved in this interaction have been shown to be the bile salts. The nature of the bile salt‐erythromycin interaction has been investigated. The way in which an interaction between bile salts and erythromycin in vivo might lead to the hepatic dysfunction and cholestasis associated with some instances of erythromycin therapy is discussed.