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Depletion of B Lymphocytes in Chronic Hypoplastic Marrow Failure (Aplastic Anaemia) ‡
Author(s) -
Morley Alec,
Holmes Kerry,
Forbes Ian
Publication year - 1974
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1974.tb03234.x
Subject(s) - medicine , myelopoiesis , immunology , lymphopoiesis , surface immunoglobulin , antibody , disease , haematopoiesis , pathology , b cell , biology , stem cell , genetics
Summary: The numbers of B and T lymphocytes were measured in nine patients with chronic hypoplastic mar‐row failure and significant depletion of B but not of T lymphocytes was found. The lesion in the disease therefore appears to affect lymphopoiesis in addition to myelopoiesis. Study of surface immunoglobulin markers in three patients provided no evidence of clonal nature of the lymphocytes in the disease.