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Ineffectiveness of Dextrodopa in Chronic Granulocytic Leukaemia
Author(s) -
Spiers A. S. D.
Publication year - 1974
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1974.tb03220.x
Subject(s) - granulopoiesis , medicine , neutropenia , chronic granulocytic leukemia , immunology , chemotherapy , leukemia , haematopoiesis , stem cell , genetics , biology
Summary: The occurrence of neutropenia and abnormalities of granulopoiesis in Parkinsonian patients treated with mixtures of levodopa and dextrodopa, and not in patients treated with pure levodopa, suggests that dextrodopa depresses granulopoiesis, possibly by competitive antagonism of phenylalanine. However, treatment of patients with chronic granulocytic leukaemia with 8 g of dextrodopa daily for up to five weeks failed to control their disease. Despite these results it is considered that the use of amino acid antagonists remains a potentially valuable approach to therapy of chronic granulocytic leukaemia.