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Adrenergic Receptor Mechanisms and Renin Secretion **
Author(s) -
Vandongen R.
Publication year - 1974
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1974.tb03181.x
Subject(s) - phenoxybenzamine , endocrinology , medicine , methoxamine , renin–angiotensin system , adrenergic receptor , adrenergic , secretion , receptor , catecholamine , alpha 1a adrenergic receptor , stimulation , alpha (finance) , alpha 1d adrenergic receptor , alpha 1b adrenergic receptor , agonist , beta 3 adrenergic receptor , construct validity , nursing , blood pressure , patient satisfaction
Summary: The respective role of alphaadrenergic and beta‐adrenergic receptors in mediating the effect of catecholamines on renin secretion were examined in the isolated perfused rat kidney. Renin secretion was markedly stimulated by isoproterenol, a catecholamine with pre‐dominant beta‐adrenergic activity, but not by methoxamine which has pre‐dominantly alpha‐adrenergic effects. Selective involvement of beta‐adrenergic receptors was further supported by the specific inhibitory effect of dlpropranolol. Norepinephrine, which has combined alpha‐ and beta‐adrenergic activity, only stimulated renin secretion when the alpha‐receptor blocking agent phenoxybenzamine was present. These observations indicate an exclusive role for intrarenal beta‐adrenergic receptors in the stimulation of renin secretion. In contrast, it is apparent that an opposite inhibitory effect on renin secretion follows alpha‐adrenergic activity.