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The Rat Mast Cell Degranulation Assay as an In Vitro Allergy Test
Author(s) -
Wetherall J. D.,
Hackshaw Roslyn,
Turner K. J.
Publication year - 1974
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1974.tb03170.x
Subject(s) - degranulation , medicine , immunology , immunoglobulin e , allergy , mast cell , penicillin , pharmacology , in vitro , microbiology and biotechnology , antibiotics , biology , antibody , biochemistry , receptor
Summary: Rat mast cell degranulation has been utilised to detect human reagins to the drugs penicillin, insulin, rifampicin, cycloserine and lignacaine and to rheomacrodex. The specificity of the method for human IgE was established by the induction of degranulation with anti‐IgE. The technique appears to have limitations as a potential tool for routine clinical diagnosis.