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Bisalbuminaemia and Defective Platelets
Author(s) -
Clancy R.,
Firkin B.
Publication year - 1974
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1974.tb03169.x
Subject(s) - platelet , medicine , albumin , platelet aggregation , endocrinology , biochemistry , immunology , chemistry
Summary: A family is described with two rare familial traits — bisalbuminaemia and a platelet defect. These disorders segregated together through two generations. The abnormal albumin migrated more slowly than the normal band and had a greater binding affinity for thyroxine, but bound Bromophenol blue dye poorly. The platelet defect manifested as thrombocytopenia in one generation, and as a qualitative defect in the other, characterised by impaired platelet aggregation in response to collagen. Plasma from patients with bisalbuminaemia augmented the rate of platelet sedimentation when blood was centrifuged but did not inhibit the response of normal platelets to aggregants. It is suggested that this family demonstrates a linkage of two rare, genetically deter‐mined, disorders.