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Impairment of Immunological Function in Aplastic Anaemia *
Author(s) -
Morley Alec,
Forbes Ian
Publication year - 1974
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1974.tb03146.x
Subject(s) - medicine , toxoid , immunology , tetanus , aplastic anemia , bone marrow failure , bone marrow , immune system , immunologic function , antibody , delayed hypersensitivity , vaccination , haematopoiesis , stem cell , genetics , biology
Summary: Since the bone marrow is now believed to be the source of many of the cells participating in immune reactions immunological function was tested in eleven patients with aplastic anaemia. Nine were lymphocytopenic and seven were monocytopenic. Various abnormalities were detected, the most common being failure to show intradermal hypersensitivity in six patients and failure to produce antibody to tetanus toxoid in six. Immunological impairment may be a factor in some of the clinical manifestations of aplastic anaemia.