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Long‐Term Use of Oral Contraceptives: A Study of Chromosomes and Lymphocyte Transformation ††
Author(s) -
Fitzgerald P. H.,
Pickering Alison F.,
Ferguson Deborah N.,
Hamer J. W.
Publication year - 1973
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1973.tb04297.x
Subject(s) - medicine , lymphocyte , thymidine , family planning , mitotic index , physiology , chromosome , population , mitosis , immunology , gynecology , research methodology , genetics , dna , biology , environmental health , gene
Summary: Findings from 17 women who had unbroken histories of oral contraceptive use covering 4.5 years or longer were compared to a control group of 18 women, approximately matched for age, who had never used oral contraceptives. Anomalies of chromosome number and structure in blood lymphocytes, cultured for 48 hours with PHA, did not differ between the two groups. Lymphocyte transformation in response to PHA, as measured by mitotic index and cell uptake of tritiated thymidine, was reduced in oral contraceptive users compared to controls.