Premium
Gold Levels in Serum during the Treatment of Rheumatoid Arthritis with Gold Sodium Thiomalatet ‡
Author(s) -
Palmer David G.,
Dunckley James V.
Publication year - 1973
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1973.tb03123.x
Subject(s) - gold sodium thiomalate , medicine , rheumatoid arthritis , gold salts , gold standard (test) , gold compounds , body weight , colloidal gold , sodium , gastroenterology , endocrinology , chemistry , organic chemistry , combinatorial chemistry , materials science , nanoparticle , nanotechnology
Summary: Serum gold levels estimated in the course of therapy with gold sodium thiomalate were found to be closely related to dose and patient body weight. Maximum information was obtained from gold levels estimated on blood samples taken the day before and at 24 hours after gold administration. Serum gold levels did not reflect tissue concentrations, but provided a consistent parameter of gold metabolism during long term therapy. Individual differences in gold metabolism were apparent in serum levels estimated three weeks or more after administration.