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The Treatment of Progressive Supranuclear Palsy with L‐Dopa
Author(s) -
Donaldson Ivan MacG.
Publication year - 1973
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1973.tb03116.x
Subject(s) - progressive supranuclear palsy , medicine , disease , drug , parkinson's disease , progressive disease , surgery , pharmacology
Summary: Two cases of progressive supranuclear palsy were treated for sever‐al months with substantial doses of L‐dopa. Both showed no significant response and continued to deteriorate while on this drug. Because of the sites of maximal involvement, and the extensive nature of the disease process, substantial improvement with L‐dopa would seem less likely in this condition than in Parkinson's Disease. This is con‐firmed by the few previously reported cases treated with this drug. The rate of progression of the disease would suggest that any response obtained would be of short term benefit only.